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Depression-era movie star Deanna Durbin dies

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Deanna Durbin

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Deanna Durbin in 1940's "It's a Date."

She was a child star with a striking singing voice who retired from the business in her twenties, but Deanna Durbin, whose death at 91 was announced Tuesday, remained a beloved screen actress long after her star had faded.

The Deanna Durbin Society's newsletter announced her death, quoting her son Peter H. David, said the New York Times. He indicated that she died "a few days ago," but provided no other details. He also thanked fans for respecting her privacy.

Born in Winnipeg, Manitoba in 1921, Durbin was a familiar face to the Depression-era audiences who flocked to movie houses. Signed to MGM at 13, she made her first film alongside Judy Garland in the 1936 short "Every Sunday." The oft-repeated story is that MGM head Louis B. Mayer, away on a trip, instructed his employees to "drop the fat one" from the studio's contract -- and they let Durbin go, but Mayer had meant Garland.

She was picked up at Universal and the subsequent success of her next films, including "Three Smart Girls" (and its two sequels) were credited with keeping the studio aloft. A 1936 nationwide search for the actor who would give her her first screen kiss made news, and Robert Stack was the actor chosen for "First Love."

By 1946 she was the second-highest paid woman in America, just $5,000 behind Bette Davis. At the height of her success she was so internationally-recognized that Anne Frank had her picture on the bedroom in the attic where she and her family lived; the photo still hangs today.

Durbin was often cast in musicals, and had a clear soprano that permitted her to cover a range from pop tunes to opera. Still, when she auditioned for the lead role in Disney's "Snow White," Walt Disney reportedly considered the then 15-year-old as sounding mature for the part. She recorded dozens of songs, including recreations of her movie tunes that were released commercially, and standards including "Love's Old Sweet Song" and "God Bless America."

Unfortunately, she had a harder time adjusting to the light, fluffy roles that had brought her early success; critics weren't happy to see her as a prostitute in 1944's "Christmas Holiday," for example. It also affected her personal relationships, and she divorced her husband of two years, director Vaughn Paul, in 1943. She was married twice more, to producer Felix Jackson and Charles David (director of "Lady on a Train"). Her union with David lasted from 1950 until 1999, when he died.

Durbin made her last film in 1948 ("For the Love of Mary") and retired to a French farmhouse with David, never again dipping her toes into Hollywood waters. She gave almost no interviews, but was quoted in the Times as having said "I hated being in a goldfish bowl."

A letter she sent reporters in 1958 read in part: "I was a typical 13-year-old American girl. The character I was forced into had little or nothing in common with myself -- or with other youth of my generation, for that matter. I could never believe that my contemporaries were my fans. They may have been impressed with my 'success.' But my fans were the parents, many of whom could not cope with their own youngsters. They sort of adopted me as their ?perfect? daughter.?

She added, "I was never happy making pictures. I?ve gained weight. I do my own shopping, bring up my two children and sing an hour every day."

Source: http://www.today.com/entertainment/deanna-durbin-depression-era-film-heroine-singer-dead-91-6C9692845

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Win a $100 Sears Gift Card by Playing Sears LocalAd #Sweeps ...

This is a sponsored post. I am a Sears blogger, though all opinions are my own.

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Source: http://www.thenotsoblog.com/2013/04/win-a-100-sears-gift-card-by-playing-sears-localad-sweeps/

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The Call Blog: Mayor Bloomberg Says NYPD Is "Under Attack" By Critics

Have something to tell us at The Call? Drop us a line at thecall@ny1.com and we'll post it to our blog.



City Comptroller and mayoral candidate John Liu put it perfectly today when he said, "[The Mayor's] presenting a false choice, that people either are safe, or people have rights." New Yorkers have a right to feel safe in their neighborhoods. They shouldn't fear criminals, nor should they fear racial profiling and mistreatment from those who are sworn to protect them.



Mayor Bloomberg launched into a spirited defense of the NYPD after meeting with top police brass today. Bloomberg said "the NYPD is under attack" by mayoral candidates who are "playing politics with public safety." He said those who want to reform Stop, Question and Frisk and create an Inspector General to oversee the department have no role in keeping New York City safe.

The 22-minute speech was described by the Associated Press as a "stepped-up, aggressive response to those who question whether the nation's largest police department has overstepped its bounds." Public Advocate and mayoral candidate Bill de Blasio called the speech "fear-mongering." What do you say?

Are criticisms of some of the NYPD tactics justified? Do you agree with Mayor Bloomberg that police are "under attack" by candidates looking to score political points? Do you want to see an Inspector General position created? Would you reform Stop, Question and Frisk?

Send your thoughts using the link above.



Like a kid mayor Bloomberg likes to throw a tantrum when you criticize anything his administration does, and in the case of stop and frisk there is plenty to criticize, most glaring is statistics that show the a high percentage of those stopped are Latino or Black who are eventually let go far lack of evidence, statistics also show that the policy does not reduce crime as much as it does in creating friction between communities of color and the police, further hampering crime fighting efforts.

Felix Bay Ridge



He's losing it and quickly because now this dictatorship that he has created is
slipping away and by no means am I in favor any of these so called wanna be
politicians.

The first phone call to you yesterday was i believe a council member. She and
all the others which also play the role of bobble head have no polish. This is
not a game. This is New York and we have had enough of all of these same old
faces and the new creations by this Quinn is a joke.

Quinn looks as though she has already taken over and these people are a
creation of what she has become. So here's where it gets this is when she start
to play the spiteful game of hers and holds back funds which are i might ad are
our hard earned tax payers money.

SOMEONE HAD BETTER REEL HER IN!
WHAT I WOULD LIKE TO KNOW IS WHAT HAS SHE AND
ALL THE OTHERS ACCOMPLISHED IN THEIR 3RD TERMS.
YOU ALL ARE GETTING PAID AND YOU STILL HAVE A FEW
MONTHS TO GO BEFORE WE SAY SAYONARA!

maxxiee
mp



Amazing that Bloomberg is sticking up for the NYPD while he puts the NYC Teachers down every chance he gets.

However, the NYPD deserve all the praise available. They do a great job each and every day and risk their lives every time they walk out their front door. I believe the NYPD is doing well and there is no need for an Inspector General's position. Take that money and give the NYPD a new contract with a pay increase. Bloomberg's big on putting people at desks, doing nothing. That's true for every City department.

Jessica, Arden Heights, Staten Island



Fear mongering. All I heard is 9/11 and Boston. This is also to prop up Quinn. The whole thing was a shame.

Rich Midtown East



Criticism of some NYPD tactics are justifiable and the police are not under attack as mayoral candidates are telling the truth. NO we do not need an IG, just the discontinuance of stop question and frisk, a blatant form of racial profiling.

Joyce
Springfield Garden, NY



Criticisms of the police are justified. Criticisms of the Mayor are also justified.

Joe
Port Richmond, SI



I agree with the Mayor. Mayoral Candidates are using public safety as a stepping stone to office, unfortunately there is no middle of the road when it come to public safety. If stop and frisk goes away, who wins? But the bigger question is, who loses?

Roscoe
Park Hill



It can be fine-tuned but frankly although I'm pretty Liberal regarding civil liberties in an era of enemy Jihadist combatants who are Americans requiring they be Mirandised Im fine with stop and frisk. We live in a dangerous world and political correctness and terrorism are oxymoronic in many instances. Its good reality testing and sound Law enforcement.

JS
Flushing



I agree with the Mayoral Candidates, I would like to see an Inspector General overseeing the police. The police need some supervision because this "stop and frisk" have only served to harass minority citizens. They have become vigilantes and a lot of them make the streets unsafe.

Theresa
Upperwestside



It's called politics. Mr. Mayor can dish it out but can't take the heat. Who is the mayor intending to stop, question and frisk? Is he going to go to Times Square and frisk people who a police officer thinks is suspicious? Is he going to Madison Avenue? If not, he's saying terror suspects come from poor, minority communities.

Tony



The candidates are obviously playing to the minority vote and will change nothing once in office. Dirty politics rules yet another mayoral election.

Steve
Forest Hills



The mayor and rabid Doberman police commissioner Kelly think safety is paramount above individual civil rights and that we should genuflect at their feet. They need a IG to keep them in check and hold them accountable, and what nerve to lay ground work for the incoming mayor elect.

Joe
Middle Village



Statistics that something is effective is NEVER enough to justify bypassing Constitutional rights. If unwarranted invasions into people's homes, purely through a random selection process, resulted in the regular discovery of illegal drugs and firearms, would we suddenly conclude that such government action is justified? Absolutely not. But yet we are willing to entertain Commissioner Kelleys' recitation of stats to justify the use of stop and frisk? These decisions should be made purely on a case-by-case basis, and not intentionally practiced in one neighborhood or on one race over another.

Fabio
Harlem



THE MAJOR KNOWS SOME OF HIS POLICIES ARE COMING TO A END. GOOD RIDDANCE AND DON'T LET THE DOOR HIT YOU ON THE WAY OUT.

PEDRO BRONX



Its great that the crime rate is low. But might that have something to do with the fact that NYC has about the highest living standard of any city in the world? Only wealthy people can afford to live here for the most part. And although these people commit plenty of crimes; they aren't the types of crimes which go into the stats they are referring to.

Daphne, Manhattan



THE WORLD BEING A DANGEROUS PLACE THERE WILL ALWAYS IN ONE WAY OR ANOTHER BE A FORM OF SQ&F. ITS GONNA GET WORSE.

JIMMY. BRONX



Stop and Frisk needs to be stopped. I have seen the police strip search a young white man in the street for no reason, it was absolutely horrible. I can't imagine what minorities go through. I guess it's the same reason why some NYPD officers say that they need to meet a quota of traffic tickets. Nothing that Bloomberg does makes any sense.

Anna



The mayor is one to talk about any city agency under attack!! What about his all out attack on education, public school teachers and the children of NYC!! What about his attack against the FDNY?? Now he wants to blame others for using his tactics! Under attack - Mayor Bloomberg brought this nastiness to a higher level!

Elima



700,000 stops, vs. 800 weapons found. I think the numbers speak for themselves as to how ineffective this is in terms of resources and loss of freedom.

I suspect the number is very close to what would be achieved randomly and thus indicates this is not a worthwhile process as the police cannot articulate any genuine reason for most of the stops that could be considered as being derived from trained policing.

"The right of the People to be secure in their Persons..." is not just meaningless drivel.

When you fear to walk down a public street because of armed, dangerous people stopping you and demanding things of you for no real reason, it matters little if they are gang bangers,police or government officials, you are not secure.

One of the most basic freedoms is the right to simply be left alone.

Angel in Harlem

The stop and frisk policy is about as racist and denigrating and anything could get. How would Bloomberg like it if Jews were targeted for some sort of harassment because the "might be up to no good?"

Frances
East Village



That guy Richard that just called is a lying idiot. Of course now that NYPD stats don't support his viewpoints, he has black friends from the projects that hide guns from police. What a convenience!

Tiffany



the idea that blacks and latinos are more likely to commit crimes is an evil stereotype...stop and frisk should be tried in white neighborhoods lets c how long they could have gotten away with it

Nasrtaha



Of course these are unimpressive politicians trying to impress the minority communities that basically they will allowed to continue committing crimes. Until there family member is gunned downed and then they'll be singing a different tune.

This is a pathetic group of mayoral wannabees. I really think we are going to be in big trouble if any of them becomes our next mayor.

God Bless the NYPD.

kate
midtown east



I say stop all stop and frisk. Instead give harsh prison time when caught with a gun or for using a un. It's time to get rough with criminals

mnmnus



All of the people complaining about stop and frisk argue that only 10% result in arrests. Why isn't anyone talking about the 10% of murderers, rapists, bail jumpers, fugitives wanted in other jurisdictions and people with outstanding warrants that are taken off the street and compelled to face justice. Stop playing the race card. It's so old.

Eddie



Half a million unwarranted stops, militarized police patrolling with heavy weaponry, bag searches without probable cause at subway entrances, unlawful arrests and mass sweeps at political protests such as the RNC and Occupy-you live in a security state-a police state-with demagogues like Bloomberg the politics of the National Socialists live.

Carl
Soho



I can not believe that anyone would associate stop and frisk with probable cause. The police have always had the right to stop someone under probable cause, even enter your home. That law has been on the books for over 50 years. Stop and frisk serves only one purpose, Minorities are targeted. It servers no purpose except to build hostility against the public towards the police. If this was the Mayors children being harassed, he would have got rid of it himself a long time ago. But as we all know he would not allow that in his neighborhood.

Raheem from Jamaica Queens



In Bloomberg's NY, stop and frisk is just a euphemism for racial profiling. However, this policy works because young black and hispanic men commit most of the street crime.

Steve
College Point



Rudy G. was considered tough on crime, but the NYPD only stopped 100,000 a year versus Mike's 700,000 a year! This is why the NYPD is being criticized. It is the Mayor's fault for giving Kelly Carte Blance, and the cops are paying for it.

Mario
Chelsea



I don't get it. I am black, and I see how the youth act. They are animals. I have no problem with stop n frisk. The blacks and Hispanic commit most of the gun crimes in Ny.

I am so tired or The blacks and Hispanic crying wolf(color).

Naqam



Is stop and frisk racial profiling and a form of discrimination -- there seems to be two sides to this story and a matter of opinion. However it is quite telling that the vast majority of stop & frisks are of Hispanics and Black men. But Mayor Bloomberg 's claim that he never plays politics with peoples' lives is outrageous. Is he not the one who plays politics with the lives of children in NYC with his educational policies? Is he not the one who is plays politics when he opens charter schools and closes public schools over the massive cries of parents and children? And now does it not appear that he is playing politics with the lives of New Yorkers by outwardly criticizing Ms. Quinn through the front door but politically supporting her through the back door?

Perhaps Mayor Bloomberg is correct that Stop & Frisk policy is the first line of defense against crime in New York City and maybe the NYPD is not racial profiling. But one thing is for sure Mayor Bloomberg is undoubtedly the Master of the Masquerade.

Lisa
Upper east side



It was embarrassing to witness Bloomberg's rant about the virtue of civil right's violations by the NYPD. Even the audience of NYPD personnel gave a tepid applause. It was hard to watch, the feeble rationale with ringing racist undertones.

k
harlem



Nearly 90% of stops lead to no arrest or summons.

Less than 1% result in the recovery of a gun/weapon.

John indicated that the 90% number had to with not finding a weapon. The weapon failure rate is actually approximately 99%; the arrest/summons failure rate is nearly 90%.

Mandela
Downtown Brooklyn



Its funny how most of the people in favor of stop and frisk, live affluent neighborhoods and are white..smh

Kyle from East Harlem

Source: http://www.ny1.com/content/the_call/the_call_blog/181293/the-call-blog--mayor-bloomberg-says-nypd-is--under-attack--by-critics

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Silicone liquid crystal stiffens with repeated compression: Discovery may point toward self-healing materials

Apr. 29, 2013 ? Squeeze a piece of silicone and it quickly returns to its original shape, as squishy as ever. But scientists at Rice University have discovered that the liquid crystal phase of silicone becomes 90 percent stiffer when silicone is gently and repeatedly compressed. Their research could lead to new strategies for self-healing materials or biocompatible materials that mimic human tissues.

A paper on the research appeared this month in Nature's online journal Nature Communications.

Silicone in its liquid crystal phase is somewhere between a solid and liquid state, which makes it very handy for many things. So Rice polymer scientist Rafael Verduzco was intrigued to see a material he thought he knew well perform in a way he didn't expect. "I was really surprised to find out, when my student did these measurements, that it became stiffer," he said. "In fact, I didn't believe him at first."

The researchers had intended to quantify results seen a few years ago by former Rice graduate student Brent Carey, who subjected a nanotube-infused polymer to a process called repetitive dynamic compression. An astounding 3.5 million compressions (five per second) over a week toughened the material, just like muscles after a workout, by 12 percent. What Verduzco and lead author/Rice graduate student Aditya Agrawal came across was a material that shows an even stronger effect. They had originally planned to study liquid crystal silicone/nanotube composites similar to what Carey tested, but decided to look at liquid crystal silicones without the nanotubes first. "It's always better to start simple," Verduzco said.

Silicones are made of long, flexible chains that are entangled and knotted together like a bowl of spaghetti. In conventional silicones the chains are randomly oriented, but the group studied a special type of silicone known as a liquid crystal elastomer. In these materials, the chains organize themselves into rod-shaped coils. When the material was compressed statically, like squeezing a piece of Jell-O or stretching a rubber band, it snapped right back into its original shape. The entanglements and knots between chains prevent it from changing shape. But when dynamically compressed for 16 hours, the silicone held its new shape for weeks and, surprisingly, was much stiffer than the original material.

"The molecules in a liquid crystal elastomer are like rods that want to point in a particular direction," Verduzco said. "In the starting sample, the rods are randomly oriented, but when the material is deformed, they rotate and eventually end up pointing in the same direction. This is what gives rise to the stiffening. It's surprising that by a relatively gentle but repetitive compression, you can work out all the entanglements and knots to end up with a sample where all the polymer rods are aligned."

Before testing, the researchers chemically attached liquid crystal molecules -- similar to those used in LCD displays -- to the silicones. While they couldn't see the rods, X-ray diffraction images showed that the side groups -- and thus the rods -- had aligned under compression. "They're always coupled. If the side group orients in one direction, the polymer chain wants to follow it. Or vice versa," Verduzco said.

The X-rays also showed that samples heated to 70 degrees Celsius slipped out of the liquid crystal phase and did not stiffen, Verduzco said. The stiffening effect is reversible, he said, as heating and cooling a stiffened sample will allow it to relax back into its original state within hours.

Verduzco plans to compress silicones in another phase, called smectic, in which the polymer rods align in layers. "People have been wanting to use these in displays, but they're very hard to align. A repetitive compression may be a simple way to get around this challenge," he said.

Since silicones are biocompatible, they can also be used for tissue engineering. Soft tissues in the body like cartilage need to maintain strength under repeated compression and deformation, and liquid crystal elastomers exhibit similar durability, he said.

The paper's co-authors include Carey, a Rice alumnus and now a scientist at Owens Corning; graduate student Alin Chipara; Yousif Shamoo, a professor of biochemistry and cell biology; Pulickel Ajayan, the Benjamin M. and Mary Greenwood Anderson Professor in Engineering and a professor of mechanical engineering and materials science, chemistry and chemical and biomolecular engineering; and Walter Chapman, the William W. Akers Professor of Chemical and Biomolecular Engineering, all of Rice; and Prabir Patra, an assistant professor of mechanical engineering at the University of Bridgeport with a research appointment at Rice. Verduzco is an assistant professor of chemical and biomolecular engineering.

The research was supported by an IBB Hamill Innovations Grant, the Robert A. Welch Foundation, the National Science Foundation and the National Institutes of Health, through the National Institute of Allergy and Infectious Diseases.

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Story Source:

The above story is reprinted from materials provided by Rice University. The original article was written by Mike Williams.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Aditya Agrawal, Alin C. Chipara, Yousif Shamoo, Prabir K. Patra, Brent J. Carey, Pulickel M. Ajayan, Walter G. Chapman, Rafael Verduzco. Dynamic self-stiffening in liquid crystal elastomers. Nature Communications, 2013; 4: 1739 DOI: 10.1038/ncomms2772

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/61Z0GEWnuTs/130429164952.htm

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Mississippi man makes court appearance in ricin letters case

By Robbie Ward

TUPELO, Mississippi (Reuters) - A Mississippi martial arts instructor appeared in federal court on Monday to face charges in connection with mailing letters containing the deadly poison ricin to President Barack Obama and other U.S. officials.

Everett Dutschke, 41, was arrested on Saturday in Tupelo, Mississippi, after authorities searched his former business and home. He is charged with developing and possessing ricin and attempting to use it as a weapon.

Wearing an orange prison jumpsuit, Dutschke responded briefly to a judge's questions at the hearing in Oxford, Mississippi, on whether he understood the charges against him. The judge ordered a preliminary hearing be held on Thursday when prosecutors will present more detailed evidence in the case.

An indictment detailing the charges is under seal but could be made public later on Monday, said George Lucas, Dutschke's court appointed attorney.

Dutschke has denied having any involvement with the ricin letters and said he cooperated with federal officials during their searches.

He faces a possible life sentence if convicted.

Dutschke's arrest came nearly two weeks after suspicious letters intended for Obama and U.S. Senator Roger Wicker of Mississippi were intercepted in Washington. Tests showed they were tainted with ricin, a highly lethal poison made from castor beans. A separate ricin-lased letter was also sent to a Mississippi judge.

Authorities initially arrested another Mississippi man, Kevin Curtis, in the case but dropped the charges last week after a search of his house failed to turn up any evidence of his involvement.

Dutschke's name surfaced at a court hearing when Curtis' attorney suggested someone framed her client and mentioned a running feud between the two men.

He also faces charges in a separate case related to an April 1 indictment for fondling three children between ages 7 and 16, from 2007 to 2013, according to court records.

The ricin-tainted letters were discovered just days after the bombings of the Boston Marathon and during the massive police manhunt for those responsible, helping to fuel anxiety in the United States, especially in the capital.

The case rekindled memories of the 2001 U.S. anthrax attacks that killed five people and puzzled investigators for years. The Justice Department later said that a U.S. scientist who committed suicide was responsible.

(Additional reporting by Kevin Gray in Miami.; Editing by David Adams and Andrew Hay)

Source: http://news.yahoo.com/mississippi-man-appear-federal-court-ricin-letters-case-100352159.html

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'Teen Mom' Farrah Abraham sells sex tape

TV

10 hours ago

"Teen Mom star Farrah Abraham attends the Colgate Optic White Beauty Bar at 901 Salon With Skinmate, Fake Bake and Cetop...

Getty Images file

"Teen Mom" star Farrah Abraham's sex tape has been purchased by Vivid Entertainment.

There?s never a dull moment when it comes to ?Teen Mom? Farrah Abraham. On Monday, Vivid Entertainment announced it had purchased the adult movie featuring the MTV starlet and porn star James Deen. In a press release, Vivid founder Steven Hirsch confirmed that his company had obtained the rights to the movie and would be releasing it next month.

?We went after this movie as vigorously as any sex tape we?ve ever pursued,? Hirsch said in a statement. ?We felt it was definitely worth it, not because of Farrah?s popularity, but because the footage itself is amazing.?

Related: Dr. Phil slams entitled 'Teen Mom' Farrah Abraham

Hirsch also compared the "Teen Mom" star to another reality TV personality, saying in his statement, "Farrah's looks remind me of a young Kim Kardashian and we all know how her story turned out."

Abraham has not yet replied to a request for comment.

Related: James Deen: I refused to pretend to date 'Teen Mom' Farrah

Also on Monday, her attorney appeared in a Nebraska courtroom on her behalf and entered a not guilty plea to all three charges stemming from her DUI arrest last month. Abraham, who was charged with aggravated DUI, refusal to take a field sobriety test and disorderly conduct, still hasn't taken responsibility for her actions that night, telling TMZ Live last month that she was ?put in a very bad situation? by her sister, Ashley, whom she blames for the incident.

Abraham?s next court date is set for May 31.

Source: http://www.today.com/entertainment/teen-mom-farrah-abraham-sells-sex-tape-6C9674690

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Cell response to new coronavirus unveils possible paths to treatments

Cell response to new coronavirus unveils possible paths to treatments [ Back to EurekAlert! ] Public release date: 30-Apr-2013
[ | E-mail | Share Share ]

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases

NIH-supported scientists compare novel coronavirus to SARS coronavirus

WHAT:

NIH-supported scientists used lab-grown human lung cells to study the cells' response to infection by a novel human coronavirus (called nCoV) and compiled information about which genes are significantly disrupted in early and late stages of infection. The information about host response to nCoV allowed the researchers to predict drugs that might be used to inhibit either the virus itself or the deleterious responses that host cells make in reaction to infection. Since nCoV was recognized in 2012, 17 confirmed cases and 11 deaths have been reporteda high fatality rate that is spurring urgent research efforts to better understand the virus and its effects.

The investigators, led by Michael G. Katze, Ph.D., of the University of Washington, compared cellular gene expression responses to two viruses: the novel coronavirus and a coronavirus that caused a global outbreak of severe acute respiratory syndrome (SARS) in 2003. Although the viruses are in the same family, their effects on human cells are vastly different. In general, nCoV disrupted a greater number of human genes more profoundly and at more time points after infection than the SARS coronavirus. The team identified one set of 207 human genes whose expression differed from normal soon after infection with nCoV and remained disrupted throughout the course of infection. Notably, nCoV down-regulated the activity of a group of genes involved in signaling the presence of an invading virus to the immune system. Such down-regulation may cause a delay in the infection-fighting response.

The researchers used computational approaches to determine that certain classes of drugs, including specific kinase inhibitors and one type of glucocorticoid, act on some of the 207 human genes whose expression was found to be disrupted by nCoV. The team hypothesized that treatment with such drugs might block nCoV replication and disease progression in the host. In their current study, they tested this hypothesis using a kinase inhibitor on nCoV-infected cells grown in test tubes. They found that the drug did inhibit the ability of the virus to replicate. Additional studies are needed to see if kinase inhibitors could be useful alone or in combination with other drugs to treat nCoV infection in people.

ARTICLE:

L Josset et al. Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. mBio DOI: 10.1128/mBio.00165-13 (2013) (http://mbio.asm.org/content/4/3/e00165-13).

WHO:

Valentina Di Francesco, program officer, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, is available to discuss this research.

###

CONTACT:

To schedule interviews, please contact, Anne A. Oplinger, (301) 402-1663, aoplinger@niaid.nih.gov.

This work was funded by NIH, NIAID under grant number AI081680.

NIAID conducts and supports researchat NIH, throughout the United States, and worldwideto study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov/.

NIH...Turning Discovery Into Health


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Cell response to new coronavirus unveils possible paths to treatments [ Back to EurekAlert! ] Public release date: 30-Apr-2013
[ | E-mail | Share Share ]

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases

NIH-supported scientists compare novel coronavirus to SARS coronavirus

WHAT:

NIH-supported scientists used lab-grown human lung cells to study the cells' response to infection by a novel human coronavirus (called nCoV) and compiled information about which genes are significantly disrupted in early and late stages of infection. The information about host response to nCoV allowed the researchers to predict drugs that might be used to inhibit either the virus itself or the deleterious responses that host cells make in reaction to infection. Since nCoV was recognized in 2012, 17 confirmed cases and 11 deaths have been reporteda high fatality rate that is spurring urgent research efforts to better understand the virus and its effects.

The investigators, led by Michael G. Katze, Ph.D., of the University of Washington, compared cellular gene expression responses to two viruses: the novel coronavirus and a coronavirus that caused a global outbreak of severe acute respiratory syndrome (SARS) in 2003. Although the viruses are in the same family, their effects on human cells are vastly different. In general, nCoV disrupted a greater number of human genes more profoundly and at more time points after infection than the SARS coronavirus. The team identified one set of 207 human genes whose expression differed from normal soon after infection with nCoV and remained disrupted throughout the course of infection. Notably, nCoV down-regulated the activity of a group of genes involved in signaling the presence of an invading virus to the immune system. Such down-regulation may cause a delay in the infection-fighting response.

The researchers used computational approaches to determine that certain classes of drugs, including specific kinase inhibitors and one type of glucocorticoid, act on some of the 207 human genes whose expression was found to be disrupted by nCoV. The team hypothesized that treatment with such drugs might block nCoV replication and disease progression in the host. In their current study, they tested this hypothesis using a kinase inhibitor on nCoV-infected cells grown in test tubes. They found that the drug did inhibit the ability of the virus to replicate. Additional studies are needed to see if kinase inhibitors could be useful alone or in combination with other drugs to treat nCoV infection in people.

ARTICLE:

L Josset et al. Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. mBio DOI: 10.1128/mBio.00165-13 (2013) (http://mbio.asm.org/content/4/3/e00165-13).

WHO:

Valentina Di Francesco, program officer, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, is available to discuss this research.

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CONTACT:

To schedule interviews, please contact, Anne A. Oplinger, (301) 402-1663, aoplinger@niaid.nih.gov.

This work was funded by NIH, NIAID under grant number AI081680.

NIAID conducts and supports researchat NIH, throughout the United States, and worldwideto study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov/.

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Source: http://www.eurekalert.org/pub_releases/2013-04/nioa-crt043013.php

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